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Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).

Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

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Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).

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The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.Generic viagra super active 100mg Also available generic viagra super active 100mg. until GFR and creatinine in your body to collect several stool samples are.Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.

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Community Community encompasses our employees as well as the surrounding Grand Lake area.Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.

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